Jillian Bell stars as Brittany Forgler, a broke and down-on-her-luck woman in her late 20s who moved from Philadelphia to New York to pursue a career that didn't quite pan out. Her quest for success doesn't motivate her so much as dropping out for fear of failure. She has a job she is ill-suited for and is overweight, spending much of her time living in the shadow of her perky and pretty roommate Gretchen, going to clubs where she buries her feelings into a toxic combination of drinking, drugs, casual sex, and less-than-healthy food. A doctor's visit to try to score some Adderall leads her to discover that her weight has gotten quite far away from her, to the point where it is affecting her health, both physically and mentally. She needs to lose about 50 lbs. to get to avoid further health issues of a BMI in the obese range. Due to the high cost of joining a gym without much income, Brittany begins jogging for exercise, starting with a trip around the block, but discipline is a challenge, as is putting herself out there for the world to see. She soon joins a club for runners in the city along with her soon-to-be-divorced neighbor Catherine (Michaela Watkins) and her newfound and newfound running friend, Seth (Micah Stock). She even gets a new job dog-sitting for some well-to-do types who are away for long periods, where she meets the ultimate slacker co-worker in Jern (Utkarsh Ambudkar), who convinces her to squat in their employers' abode. To keep her motivated, she and her friends set out to compete in the next New York City Marathon, but to do that requires the kind of discipline she's never known up to that point in her life. Paul Downs Colaizzo writes and directs this comedy-drama.