Rosanna Arquette stars as Roberta Glass, a dreamer New Jersey housewife who contents herself to reading about the mysterious lives of others through perusing the personals in the local paper. One in particular has caught her eye, involving “Jim and Susan” (Susan is played by Madonna) who use the ads in order to meet in public places. Curious Roberta heads out to catch a glimpse of the two when they meet in New York City, and. through a mishap, ends up with amnesia, not to mention a case of mistaken identity that sees her playing the role of being Susan herself. Trouble is, the artsy hipster Susan is being followed by a crazed thug (Will Patton) intent on recovering some heisted priceless Egyptian artifacts that end up given to Jim, earrings that have been seen in the real Susan's possession. With the help of Jim's friend Dez (Aidan Quinn), who also mistakenly thinks Roberta is Susan, she must traverse this dangerous territory and find meaning to her own life, even if she has to live the life of another to do it. Susan Seidelman directs this whimsical, artsy farce.